Pathan, TabreskhanSayyed, Mohd Kaif (23DPH08)Tambey, Muskan Ashraf (22PH102)Sayyed, Nazreen Alam (22PH68)Shaikh, Mohd. Saif (22PH86)Shaikh, Uzma Firdous (22PH95)2026-06-302026-06-302026-06http://aiktc.ndl.gov.in/handle/123456789/4528Migraine is a chronic, recurrent neurovascular disorder characterized by pulsating headache episodes accompanied by sensory, neurological and autonomic disturbances. Mucoadhesive buccal films are designed to adhere to the buccal mucosa and provide rapid and efficient systemic drug delivery by bypassing hepatic first-pass metabolism. This route offers significant advantages in the management of migraine, particularly during acute attacks associated with nausea and vomiting, where oral administration becomes less effective. The present study aims to develop and evaluate a mucoadhesive buccal film for the treatment of migraine using herbal extracts.The buccal films were formulated using suitable film-forming polymers such as hydroxypropyl methylcellulose (HPMC) and polyvinylpyrrolidone (PVP) by the solvent casting method. Standardized extracts of Zingiber officinale (ginger) and Tanacetum parthenium (feverfew) were incorporated into the formulation for their synergistic anti-migraine activity. The prepared films were smooth, flexible, and exhibited uniform drug distribution, ensuring ease of application and patient comfort.The formulated buccal films were evaluated for physicochemical and mechanical properties including thickness, weight uniformity, folding endurance, surface pH, swelling behavior, drug content uniformity, and mucoadhesive strength. In vitro drug release studies demonstrated rapid onset and effective release of active constituents. The films showed good mucoadhesion, adequate mechanical strength, and fast disintegration, facilitating quick drug absorption through the buccal mucosa.Overall, the developed mucoadhesive buccal film represents a promising, natural, and patient-friendly alternative to conventional migraine therapies. It offers rapid relief, improved bioavailability, and enhanced patient compliance, making it a potential approach for both acute and preventive management of migraine. Key Words : Migraine; ; Buccal film; Ginger; Feverfew; Mucoadhesion. .en-USProject Report