Gaikwad, MadhuriKhan, Maseera Banu Fazlur Rehman (16PH23)Quadri, Heena Kausar Mohammed Umer (16PH36)Khan, Uzma Khatoon Abdul Muttlib (16PH28)Khatib, Rahil Abdul Rauf (16PH29)2021-11-122021-11-122020-05http://localhost:8080/xmlui/handle/123456789/3678Acne often debuts during changes in hormonal level in pre-teens and also caused by the bacteria P. Acnes. The isolation of the herbal active principle and the determination of their structure, in order that they are synthesized or simply extracted more efficiently. Allopathy means modem scientific medicine which leads to adverse drug reaction as allopathic drugs are in chemical form. As Dr. Manoj Nesari joint adviser department of Ayush states that "there is rising trend towards Ayurveda". And the demand for herbal products world-wide has increased at an annual rate of 8%. Manjistha commonly knows as Rubia Cordifolia works on P. Acnes and its anthraquinone rich constitutent also contains anti-inflammatory, anti­ bacterial and anti-oxidant propety. The cream, gel and ointment formulations are prepared using alcoholic, water and alcoholic extract respectively. The formulations are characterized and evaluated on the basis of its organoleptic properties, pH values, viscosity measurement, spreadability, stress testing and determination of invitro anti-acne activity. The organoleptic properties shows that the formulations are cosmetically appealing. Cream was found to be oil soluble and pH values of formulations was found to be stable after 2 weeks. Viscosity was found to be 1500-2000 cp. Spreadability of formulations was found to be in range of 10-25 mm. Stress testing shows that the formulation has good shelf-life. And the antimicrobial activity is compared between cream, gel and ointment. Keywords Acne, P.acnes, herbal products, Manjistha, anti-inflammatory property, anti-bacterial property, anti-oxidant, property, gel, cream, ointment, anti-acne activity, anti-microbial activity.enProject Report - SoPProject Report