Research - School of Pharmacy

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Browsing Research - School of Pharmacy by Author "Shaikh, Abusufyan"

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    Comparative in vitro antidiabetic and antioxidant activity of various extracts of Ficus specie
    (Pharmacogn J., 2018) Shaikh, Abusufyan
    ABSTRACT Introduction: Ficus religiosa, Ficus benghalensis and Ficus glomerata are plants from Ficus species used traditionally for the treatment of various ailments. This study aimed to investigate in vitro antidiabetic and antioxidant activity of three plants from Ficus species and effect of extracting solvents, total flavonoids and phenolics content on its in vitro activity. Methods: Dried leaf powder was extracted successively by using solvents with increasing order of polarity index (PI). In vitro antioxidant (RP: reducing power assay, DPPH: 2,2-diphenyl-1-picrylhydrazyl assay and HP: Hydrogen peroxide assay) and antidiabetic (αA: α-amylase assay and αG: α-glucosidase assay) activities as well as total flavonoid (TF) and total phenolic (TP) contents of extracts were evaluated. The correlation between in vitro activities and solvent polarity index, total flavonoid and phenolic content were established by using pearson’s correlation coefficient (R). Results: Strong positive correlation was observed with PI of extracting solvents and TP content of Ficus religiosa (PI/ TP, R=0.8159) and Ficus glomerata (PI/ TP, R=0.9172). Comparatively benzene and water extracts of Ficus glomerata were found to have significantly (P<0.05) highest in vitro antidiabetic and antioxidant activity respectively. Strong positive correlation was observed between TF and αG inhibitory (TF/ αG, R=0.793) effects of Ficus benghalensis. In addition, strong positive correlation observed between TP and antioxidant activity (TP/DPPH, R=0.9744; TP/RP, R=0.9514 and TP/HP, R=0.8108) of Ficus glomerata. Conclusions: Finding of our research will help in selection of solvents for extracting antidiabetic and antioxidant rich phytoconstituents from Ficus species.
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    Herbal Drugs for diabetic treatment: an updated review of patents
    (Recent Patents on Anti-Infective Drug Discover, 2012) Shaikh, Abusufyan; Shaikh, Ajaz A.
    Diabetes mellitus is the most common endocrine disorder, affecting 16 million individuals in the US and 200 million worldwide....
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    Nanoemulsion as vehicle for transdermal permentation of antihypertensive drug
    (International Journal of Pharmacy and Pharmaceutical Sciences, 2012) Shaikh, Abusufyan
    Hypertension is a chronic disease which required lifelong therapy. But most of antihypertensive drugs available today, showed extensive first-pass metabolism and low oral bioavailability which can be overcome by preparing its Transdermal Drug Delivery Systems....
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    Prokinetic effect of Herbomineral unani formulation (Dolabi) in Diabetic rats
    (Journal of Research and Education in Indian Medicine, 2012-03) Shaikh, Abusufyan
    This study was undertaken to investigate the prokinetic activity of Unani herbomineral formulation (Dolabi) in streptozotocin induced diabetic rats and its in vitro antioxidant activity.