Browsing by Author "Baig, Mirza Anwar"

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    Evaluation of herbal formulation for diuretic activity in experimental animals
    (AIKTC, 2020-05) Baig, Mirza Anwar; Bhosale, Monika Bandu (16PH11); Bhanushali, Hetal Rajesh (16PH09); Gaikwad, Abhijeet Siddheshwar (16PH16); Daud, Ibrahim Shaikh Shaukat (16PH14)
    Objective: The present study was designed to evaluate the diuretic activity of herbal formulation (Gokhru Kadha). To investigate/propose probable mechanism of action of herbal formulation. Method: Animals were divided into 5 groups of 6 Swiss mice each. Group 1 served as control and administered with vehicle. Groups II, III and IV: Served as treatment group and a single dose of 20 mg, 40 mg and 60 mg/kg of HF administered orally to group II, III and IV respectively. Group V: Served as standard, treated with furosemide (10 mg/kg), and dissolved in 0.9% normal saline with CMC. Two days prior to experiments, mice were kept in metabolic cages with free access to food and water for acclimatization. Four hours before testing, the animals were fasted, with free access to drinking water only. All animals were given an oral loading of normal saline (5% by wt.). For Acute- Freshly prepared doses of test and standard drug were administered to test and standard animal group respectively. Immediately after dosing, animals were kept in metabolic cages for 6 hours and finally urine was collected, measured and filtered at the end of 6 hours 8 for various biochemical estimations. For Chronic- Daily doses of test and standard drugs were given to 4-hour fasted test and standard drug animal groups respectively for 8 days. Urine volume, urinary electrolyte level will be estimated on 24 hrs. collected urine. On 8th day, additionally urinary glucose will be estimated. Result: The Polyherbal formulations produced significant increase in Na+, K+, Cl- excretion, caused alkalinization of urine, showed strong Diuretic index, saluretic index and Natriuretic index. The higher dose of HF produced comparable effect to that of furosemide. Conclusion: As evidenced by the outcome of this study, it is reasonable to infer that the gokhru Kadha possess a significant diuretic activity in mice. Further in-depth studies are required to assess the diuretic activity in combination with the synthetic drugs and to elucidate possible mechanism of action.
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    Evaluation of invitro antidiabetic, antibacterial and Antioxidant effect of phenolic acid
    (AIKTC, 2022-05) Baig, Mirza Anwar; Shaikh, Juned Mohd Jamil (18PH70); Shaikh, Sufreen Banu Abdul Rehman (18PH84); Siddiqui, Murshida Bakar Husain (18PH94); Shaikh Bushra, Firdous Mohammed Asif (19DPH03)
    The in-vitro evaluation of antidiabetic, antibacterial, antioxidant activity of caffeic acid was investigated. α amylase inhibition was measured as it is a key enzyme in carbohydrate metabolism. Antioxidant effect was measured by hydroxyl radical scavenging and DPPH method. For antibacterial activity agar well diffusion method was used and staphylococcus aureus was cultured to test it. Caffeic acid significantly inhibited α amylase, DPPH, hydroxy radical scavenging activity. The current study proves that the caffeic acid showed significant antidiabetic, antibacterial and antioxidant effects in vitro studies.
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    Formulation and evaluation of solid dispersion incorporated oro-dispersible tablet
    (AIKTC, 2022-05) Baig, Mirza Anwar
    Indomethacin is a Non-Steroidal Anti-Inflammatory (NSAID) drug that is used in the treatments of osteoarthritis, bursitis, tendinitis, rheumatoid arthritis, gout, ankylosing spondylitis, and headaches. Indomethacin has a short and unpredictable oral bioavailability due to the drug's poor solubility in the gastrointestinal tract's fluids (GIT) To enhance the aqueous solubility of insoluble drug, polymeric carriers have been used. The investigation of this study was to formulating, evaluating and characterizing solid dispersion of Indomethacin with PEG 6000 and PVP K30 for increasing its dissolution rate and bioavailability. The solid dispersion was formulated by kneading method. The solid dispersion were characterized by Fourier transform infrared spectroscopy. The powder blend were evaluated for pre-compressional studies like bulk density, tapped density, carr’s compressibility index, Hausner ratio and post compressional studies like hardness, friability, wetting time, dissolution test. All the pre and post compressional parameters evaluated were within the pharmacopoeial limits. Indomethacin spectra shows a prominent peak at 320nm which indicates trace amount of methanol did not interfere in absorption. It was concluded that range of absorption lies in ranges of 0.1 to 0.4 and hence it follows beer lambert law. The r² value was found to be 0.9952. From the result it is concluded that Oro-dispersible tablets of poorly soluble drug, Indomethacin showed increased dissolution and thus enhanced bioavailability, improved efficacy and improved patient compliance.
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    Knowledge, attitude, practice of pharmacovigilance Amongst medical practitioners, pharmacy faculties and students in Navi mumbai
    (AIKTC, 2022-05) Baig, Mirza Anwar; Shaikh, Irfan Mohammed Hanif (18PH69); Shaikh, Saima Shahid (18ph81); Shaikh, Sarfaraj Ahmed Athar Hussain (18PH82); Siddiqui, Farhaan Mohammed Ameen (18ph91)
    It is an important factor to report an adverse drug reaction (ADR) in pharmacovigilance, this study is planned to assess the knowledge, attitude, and practice (KAP) of pharmacovigilance in pharmacy students, faculty, and doctors and the pattern of reporting system of adverse drug reaction. Design and Methods: A cross-sectional study was done over six months that uses questionnaires to evaluate the KAP of pharmacovigilance. A sample size of 700 was selected using a 95% confidence level with the raosoft online sample size calculator. A sampling method was used to select students, faculty of pharmacy, and doctors in Navi Mumbai from different departments. Data was analyzed with the SPSS 20, Tableau software for graphical evaluation, and Microsoft excel. The mean standard deviation was determined with P< 0.05 and was regulated between two attributes. Result: 427 responses were received from 700 distributed questionnaires, giving a 57% response rate. Most students who participated with 88.70% (n=291) are less than equal to 25 years old. Faculty between the ages of 25-34 responded 70.20% (n=33). Doctors less than 25 with 40.00% (n=41) and between 25-34 participated 54.30% (n=19). Conclusion: Students show a good knowledge of pharmacovigilance and adverse drug reaction reporting, although their attitude and barrier was limited. faculty showed less attitude toward reporting as compared to doctor and student. Doctors have limited KAP in PV. This study provides an insight problem in PV and there needs to be improvement with an awareness program.
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    Study of moods, behaviours, and medications of females for dysmenorrhoea
    (AIKTC, 2021-05) Baig, Mirza Anwar; Shaikh, Romana Aafreen (17PH51); Mujawar, Roshni (17PH34); Shah, Shagufta (17PH44); Siddiqui, Saheb (16PH58)
    It is estimated that more than half of all women of adolescent age suffer from Dysmenorrhoea and it often interferes with their daily physical and emotional aspects. It is the leading cause of short-term school absenteeism and is associated with a negative impact on academic and daily activities [2]. Objective- To investigate the impacts of Dysmenorrhoea, symptoms associated with it, and its self-management strategies used by students. It is very important to create awareness about the causes and treatment of Dysmenorrhoea via the education system and media. Health professional consultation must be promoted to help students who have Dysmenorrhoea. Study design-An explorative survey technique with the help of google forms. Settings and Participants- 225 female participants of age 15-45 years old (Highest participants- young women of age 21). Result- The majority of the participants experienced backache, cramps and preferred to take naps during Dysmenorrhoea. 43.1% of participants preferred very much to stay at home. 22.2% of participants experienced severe backache and 17.8% had cramps. 11.6% of young women said to have cramps on the second day. Hence, the most common physical symptom told by WHO is tallied with the results from the study. According to the data, 38.2% take medications or other remedies for Dysmenorrhoea whereas 61.7% of participants do not take any medications or use any other remedies. 34.8% prefer OTC medicines to get relief from the pain whereas 65.1% prefer natural remedies to overcome the issue.