Browsing by Author "Farhana, Nikhat"

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    Formulation and development of mouth dissolving tablets of isolated molecules and evaluation for anti-hyperglycemic activity
    (Research Journal of Pharmacy and Technology, 2014-03) Farhana, Nikhat
    Fast disintegrating drug delivery system offers a solution for those patients who are having difficulty in swallowing oral dosage forms. The present paper deals with formulation and evaluation of fast dissolving tablets from selected medicinal plants (Syzygium cuminii (L) skeel, Momordica charantia Linn Cassia auriculata Linn,) roots. A Pharmaceutical dosage form was made by using a novel constituent isolated from above mentioned plant constituents (ScReX-6b, McReX-1.CaReX-4) without and with excipients by direct compression. The tablets were evaluated for invivo and in-vitro anti-hyperglycemic activity and in-vitro hardness, friability, weight variation, disintegration time, water absorption ratio, wetting time and in vitro dissolution studies. All the formulations exhibited disintegration time in the range of 12.2 to 27.5 seconds along with rapid in vitro dissolution. It was concluded that the fast dissolving tablets of the poor soluble drug can be formulated by direct compression technique using selective super disintegrants with enhanced dissolution, taste masking and hence ensuring better patient compliance and effective therapy.
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    One POT synthesis of N-(2-nitrophenyl) acetamide
    (AIKTC, 2020-05) Farhana, Nikhat; Khan, Shifa Mohsin (15PH24); Shaikh, Taqdees Masihuzzaman (16PH57); Sumaiya Banu, Rehmansha (16PH56); Shaikh, Md Umar Imran (16PH51)
    The project was merely focusing on to carry out the disconnection approach, with existing Tylenol (acetaminophen) to develop the sustainable protocol, on one-pot synthesis. The extensive literature survey projected the background data of work done on Tylenol and its derivatives, by adopting different chemical methods, our study prime focused on to design the sustainable protocol by applying the one-pot methodology, with N-Acetylation using Mg-acetate which was the first time approach. It is also observed that the use of a catalytic amount of Mg-acetate in acetic acid is sufficient enough for smooth running of N-acetylation reactions. The procedure was chemoselective with respect to phenols, acids and alcohols. Herein we reported a simple, efficient, costeffective and environmentally benign alternative method for N-acetylation of amines using catalytic amount of Magnesium acetate in I mole of acetic acid under rotation on magnetic stirrer for 1hr at 250rpm. The reaction procedure requires no other solvent and it was a rapid process with good to excellent yields. The synthesized molecular structure was confirmed by FT-IR, NMR, and Mass spectral data during XRD-analytical diffraction scan, which suggested the complete agreement on key functionality identification structure of the molecule using powdered diffractometer preliminary analysis, the data scanned and calculated accurately with 2􀟠 coverage the detection of good reflections was noted and hence we prove, on the basis of spectra the stereochemistry of functionality was different from existing Tylenol the toxicity study and biological screening are under process in our laboratory. This project would be the novel method in the future for development of antipyretic antiviral molecules if it gave positive results for the activity. Keywords: Magnetic rotation, amines, acetic acid, Magnesium acetate, N-acetylation, chemoselectivity, Toxicity, biological screening