Browsing by Author "Khan, Firoz"

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    Antioxidants
    (AIKTC, 2018-07) Khan, Firoz
    Subject: General Chemistry; Class: F.Y. B.Pharm Sem I
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    Complexing and chelating agents used in therapy, poisons and antidotes
    (AIKTC, 2018-03) Khan, Firoz
    Subject: General Chemistry; Class: F.Y.B.Pharm Sem I
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    Evaluation of phytoconstituent for anti-parkinson activity using zebrafish as a model organism
    (AIKTC, 2020-05) Khan, Firoz; Shaikh, Mohd. Ikram Ikhlaque (16PH52); Ansari, Tamanna Vahajuddin (16PH02); Shaikh, Afzal Sharfuddin (16PH48); Saiwankar, Neeha Nooruddin (16PH40)
    Parkinson disease (PD) is the second most common neurodegenerative disorder, after Alzheimer’s disease. The incidence of PD increases after the age of 50 and rapidly increases after the age of 75. PD is characterized by motor and non-motor features. The most common motor symptoms are tremor, rigidity, akinesia (lack of movement), bradykinesia (slow movements), hypokinesia (reduced movement), that occur mainly due to the degeneration of dopaminergic neurons, involved in the movement coordination and located in the substantia nigra pars compacta. However, in later stages of the disease, it affects other brain regions. Since the available medication of the drugs for the treatment of Parkinson’s disease have seen to have many extrapyrimidal side effects and lesser drugs are present of herbal origin. The purpose of this study is to check and evaluate the efficacy of the phytoconstituent (curcumin) in treatment of parkinson’s disease using zebrafish as a model organism . Curcumin, a yellow pigment present in turmeric has been shown to exhibit numerous activities such as antioxidant, anti-inflammatory, antimicrobial, hepatoprotective, anticarcinogenic, thrombosuppressive and cardiovascular as well have potential to show anti Parkinson activity, is extracted from one of the approved methods and characterized using thin layer chromatography technique. Curcumin related to neuroprotection is its anti-oxidant function that can protects substantia nigra neurons, increases striatal dopamine level , which is necessary for the treatment of parkinson’s disease. Keywords: Parkinson’s disease, Zebrafish, Curcumin.
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    Expectorants and emetics
    (AIKTC, 2018-03) Khan, Firoz
    Subject: General Chemistry; Class: F.Y. B.Pharma Sem I
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    Lemon juice; Efficient and eco-friendly natural catalyst for one pot multicomponent synthesis
    (AIKTC, 2021-05) Khan, Firoz; Shaikh, Zarrin Banu Mohammed Arif (17PH57); Khan, Hana Tabassum Abul Wafa (17PH21); Khan, Mushahidul Islam (16PH34); Shaikh, Mohd Zishan Nasir (17PH48)
    Citric acid present in lemon juice is used as natural acid catalyst for one pot synthesis of various heterocyclic compounds with formation of products in high yield.Among other fruit extract lemon juice is given top priority for one pot multicomponent synthesis due to feature such as non toxic inexpensive, easily available, biodegradable.The catalyst is many organic reaction reflectors the importance and High expectation in kofield of research.Citric acid plays an important role as biocatalyst in the synthesis of key intermediate for the pharmaceutical and chemical industry. A multicomponent reaction (MCR) is a convergent reaction in which three or more starting material react to form a single product , where essentially all or modt of the aton contribute to the newly formed product.In recent years multicomponent reaction had gain much importance in organic synthesis, since they produced the desired product in single operation without isolating the intermediate.The advantages of MCRs are one pot reactions consume very less amount of solvent or no solvent, superior atom economy, generally takes less time compared to divergent reaction,lower cost, simple procedure and environment friendly. KEYWORDS One pot synthesis; lemon juice; biocatalyst; citric acid.
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    One-pot three component synthesis of 2,4,5-triaryl - 1h-imidazole derivatives by using lemon juice as a bio Catalyst
    (AIKTC, 2022-05) Khan, Firoz; Shaikh, Kaif Ahmed (18PH08); Choudhary, Jeehan M. (18PH17); Khan, Sirguroh M. Ilyas (18PH38); Shalgar, Laxmi Ganesh (19DPH08)
    The development of economical and environmentally friendly catalyst has a massive importance in the field of organic synthesis and is extensively needed for industrial processes. Imidazole derivatives have various properties which can be useful for treating the diseases in human population. By using the principles of green chemistry, we can synthesize imidazole derivatives using one-pot synthesis. After all the research for several years, researchers have introduced wide variety of catalyst for the synthesis of imidazole derivatives. We in this experimental analysis have used lemon catalyst for synthesising the imidazole derivatives.
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    Ratanjot coated zinc oxide nanoparticles Containing hydrogel
    (AIKTC, 2022-05) Khan, Firoz; Choudhary, Nizam Ahmad (18PH13); Chauhan, Amaan Iqbal (18PH15); Sayyed, Muskan Riyaz (18PH64); Khan, Mohammed Hamza (18PH74)
    The current study hearsays wound healing potential of zinc oxide nanoparticles (ZnONPs) hydrogel using Arnebia nobilis (A. nobilis) (Ratanjot) root extract. It makes suitable method for the green synthesis of ZnONPs and evaluation of its wound healing potential. Zinc has been used for the treatment of medical ailments for over centuries due to its accepted antibacterial and antifungal properties. The current rise of nanotechnology has provided a novel satisfying modality in ZnONPs for use in healthcare. We studied the activities of ZnONPs hydrogel. The results provide insight into the MOA of ZnONPs and have shown a positive response of a wound handling in the clinical environment.