Browsing by Author "Murugesan, Arulselvan"

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    Formulation and evaluation of medicated nano soft jelly
    (AIKTC, 2020-05) Murugesan, Arulselvan; Sayed, Ayesha Maqbool (16PH04); Bade, Uzma Nazmuddin (16PH05); Sharma, Saransh Umesh (16PH41); Gawde, Soham Dinesh (17DPH61)
    Silymarin is the extract of Silybum marianum, or milk thistle, and it is a mixture of flavonolignans (of which silybin is the most prevalent substances) and one flavonoids. It is used in different liver disorders, particularly chronic liver diseases, cirrhosis, because of its antioxidant, anti-inflammatory and anti-fibrotic power. Silymarin also helps with the digestion of fats. Silymarin is associated with poor aqueous solubility and poor bioavailability, which is due to extensive first pass metabolism. The purpose of this study is to develop and characterize medicated Nano jelly of Silymarin for increasing bioavailability and bypass extensive first pass metabolism. The medicated Nano jellies were formulated by heating and congealing method. Batches were prepared using different concentration of gelling agents and almond gum. The prepared batches were evaluated for appearance, viscosity, size less than 240nm, pH (6.54±0.5), drug content (62% to 90%), stability, and syneresis. Analysis was done using UV-Vis Spectrophotometer, FTIR & Zeta sizer. Keywords:- Silymarin, Nanojellies, Gelling Agents, congealing method
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    Magnetic nanoparticles embedded hydrogel for Wound healing
    (AIKTC, 2022-05) Murugesan, Arulselvan; Qureshi, Souleha (18PH57); Shaikh, Darakshan (18PH67); Shaikh, Rubina Banu (18PH79); Shaikh, Saima (18PH80)
    Our past few decades nanoparticles showed promising scope in the field of biomedical science in cancer treatment. Iron based nano particles MNPs mostly investigated since its role in drug delivery identified nanotechnology has gained attention of many researchers as they have unique magnetic property with size range of nano that proves to be helpful for drug delivery.
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    Systematic review on the therapeutic application of mesalazine in ulcerative colitis
    (AIKTC, 2021-05) Murugesan, Arulselvan; Khan, Ayesha (17PH20); Amruskar, Sakeeb (18DPH01); Choudhary, Saif Ali (18DPH02); Ghazi, Rehan (18DPH04)
    In 1977, mesalazine (5-aminosalicylicacid) was discovered as therapeutically active agent in treatment of ulcerative colitis (UC) and was launched in 1984 for topical and oral delivery.The drug belong to class of amino salicylate and act on the inflamed lining of the intestine (colon) so as to prevent the substance formation which causes inflammation. By this it provide relief from mild-to-moderate active ulcerative colitis. As chemically mesalazine that is 5-aminosalicylicacid is active moiety of sulfasalazine it has proven to be the first line treatment in the UC by giving its effect locally in the colon and provides relief from inflammation of Ulcerative colitis. Various formulation has been developed for increasing its efficacy starting with tablets formulation was developed with efficacy of reaching the drug to colon by pH dependent coating with polymer,Delayed release drug delivery to colon were further developed,Microbiallly triggered drug delivery to the colon which consist of (a) Prodrug approach,(b) Azo-polymeric approach,(c) Polysaccharide based approach. All this approach has proven to be efficacious but less effect was seen on colon and more concentration was getting absorbed in small intestine sometimes result in side effects. Further newly developed method were developed such as pressure controlled drug delivery system(PCDCS),CODESTM(A Novel colon targeted delivery system), Osmotic Controlled drug delivery to colon(OROSCT), Hydro gels(enema), Microspheres, Nanoparticles, Liposome’s, Multi particulate Beads. This novel approaches are made to increase therapeutic efficacy and to give targeted delivery of drug to colon. The main side effect of the drug is renal dysfunction, acute interstitial nephrotoxicity, some common side effect are rashes, headache, nausea, abdominal pain,etc. The purpose of review of articles is to determine the therapeutic application of mesalazine in ulcerative colitis by different formulation available.
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    Transdermal spray forpsoriasis treatment
    (AIKTC, 2022-05) Murugesan, Arulselvan; Siddiqui, Iqra Nadim (18PH93); Shikalgar, Azim Akhtar (18PH87); Shinde, Sagar Shashikant (18PH89); Shaikh, Mohd. Altaf (18PH77)
    Psoriasis is a chronic autoimmune disorder and it is characterized by raised thick, red patches that are covered with a silvery layer of dead skin cells.