Browsing by Author "Patil, Jayshree"

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    Green synthesis and characterization of bioactive quinazolinone schiff base
    (AIKTC, 2020-05) Patil, Jayshree; Shaikh, Heena Babu (16PH49); Satpute, Swati Kulbhushan (16PH43); Bhoir, Rahul Praod (16PH10); Pathan, Shahabaz Abdul Wahab (16PH47)
    Schiff bases have gained importance in medicinal and pharmaceutical fields due to a broad spectrum of biological activities and have been utilized as synthons in the preparation of a number of industrial and biologically active compounds. Quinazolines and quinazolinones are medicinally important nitrogen hetero cyclic compounds. The combination of unique structural features, extensive functionalization, and very high biological activity found, both building blocks are tethered together to synthesize new chemical entity (NCE) 3- (benzylideneamino)-2-methyl-quinazolin-4-one, i.e. schiff base using lemon juice as green solvent. Utilization of fruit juices as a natural and biocatalyst permits mild and highly selective transformation and synthesis in a simplistic and environmentally friendly manner. The present synthesis proceeds via synthesis of Methyl-2- acetamidobenzoate from methyl anthranilate followed by cyclization to produce 3-amino-2-methyl quinazolin-4-one which on treament with benzaldehyde produces schiff base.The synthesized product was identified by its physical properties, melting point, TLC, FTIR and characterized by NMR. It is screened for antibacterial and antioxidant properties. Compared with traditional methods, this green method was more convenient and held without generation of pollution in shorter reaction time, safer to analyst, low cost and simple to run. Keywords: Schiff base, Quinazolinone, fruit juice, bio catalyst
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    Green synthesis of dihydropyrimidinone using solvent free grinding method
    (AIKTC, 2022-05) Patil, Jayshree; Sontakke, Anjali (19DPH01); Shaikh, Rushda (19DPH06); Shaikh, Shahbaz (19DPH07); Siddiqui, Kamil (19DPH09); Khan, Tahzeeb (18PH44)
    A facile protocol for one pot (Multicomponent) synthesis of Pyrimidinone derivative through Beginelli reaction by completely different inexperienced ways like heating without catalyst, grinding within the presence of catalyst Cerric nitrate (CAN) and ammonium chloride (NH4Cl) has been performed. The reaction has been continuing smoothly below solvent free condition on grinding of mixture of various organic compound i.e Benzaldehyde, ethyl acetoacetate and urea during a mortar. Dihydropyrimidinone area unit the vital bioactive heterocyclic compounds, this has established an attention in revising the new drug entities based mostly upon the dihydropyrimidinone activity. Its intercalary importance in Pharmaceutical and medicative field thanks to its broad biological activities. The analysis is performed and compared for synthesized product exploitation completely different inexperienced ways. It's been additionally screened for antibacterial drug activity. On comparison, it's been found that grinding technique is a smaller amount time intense as compared to heating and was command while not generating any pollution in quicker time interval, safe to analyst and easy to handle. The good thing about this new protocol lies in avoiding the organic solvent, varied substrate, use low-cost or cheap catalyst that all contributes to safer chemistry.
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    Synthesis and characterization of eco-friendly bioplastic
    (AIKTC, 2022-05) Patil, Jayshree; Ansari, Mohammed Asim Hafiz Tahir (18PH01); Shaikh, Mohammad Kashif Faizan Ahmad (18PH37); Malik, Adil Aziz (18PH46); Malik, Asheya Sadeeq (18PH47); Shaikh, Mohd Raheel Abdulwaris (18PH78)
    Petrochemical based plastics are already recognized for its practice in entirely packaging industries, but petrochemical plastics produces harmful environmental issues, as its very challenging for its degradation in the environment. To minimize the detrimental effects on nature, petrochemical plastic must be replaced by bioplastic. Bioplastic is obtained from many sources such as starch-based Bioplastic, Cellulose based Bioplastic, Protein-based Bioplastic, and Aliphatic polyesters bioplastics. The making of biodegradable plastics with edible polysaccharides is economic and safe and it will definitely assist in the reduction of environmental disasters. Bioplastic can be the best substitute for conventional plastic in the diverse segments such as food packing plastic dishes of cutlery plastic, packing bags, storing flask etc. Currently biobased polymers are usually found in numerous utilization from commodity to hi-tech applications due to development in biotechnology and public awareness. The present study offers a biodegradable plastic made from tamarind seed powder. The product of the current plan has extensive industrial practices e.g. in manufacture of biodegradable art objects/household items, carry bags, wrapping/packing material etc. and also biomedical arena e.g. dressings, sutures.