Browsing by Author "Shaikh, AbuSufiyan S."

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    Comparative teratogenic and anticonvulsant activity of phenytoin and unani herbal formulation habbe sara in zebrafish (danio rerio)
    (AIKTC, 2022-05) Shaikh, AbuSufiyan S.; Chorage, Aditi Uttam (18PH16); Falke, Mehreen Mushtaque (18PH20); Kesharvani, Kajal Tulshiram (18PH27); Nair, Akhil Anil (18PH62); Wadkar, Adnan Iqbal (18PH98)
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    Study of teratogenic effect of erythromycin during embryonic development in zebrafish (danio rerio)
    (AIKTC, 2022-05) Shaikh, AbuSufiyan S.; Ansari, Mohd Aftab Md. Ashfaque (18PH04); Gupta, Roma (18PH21); Khan, Abdul Razzaque (18PH29); Khan, Humera Aleem (18PH35)
    Humans have developed many medications for their safety and for improving their quality of life. Among all the different medications antibiotics are most commonly prescribed in every disease state. Teratogenic and toxicity studies of different antibiotics to date have demonstrated significant effects in both animal models and clinical studies. The purpose of this investigation was to determine lethal concentration 10 (LC10), hatchability, mortality, and heart rate and study the teratogenic effect and toxicity of Erythromycin in the zebrafish model. Probit analysis is used to calculate LC10 value , and it was found to be 44.66 mg/L. In the case of Erythromycin hatchability decreases with increasing dose, mortality increases with increasing dose, and heart rate decreases with increasing dose. However, no effect was observed on the morphological characteristics in developing embryos of zebrafish larvae. This research can be used in considering the safety of Erythromycin for their use during pregnancy.
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    Teratogenic and hepatoprotective activity of edible lime using the zebrafish model
    (AIKTC, 2020-05) Shaikh, AbuSufiyan S.; Balabhai, Iqra Zahid (16PH06); Gupta, Shubham Suresh (16PH17); Pathan, Muskan Mohin (16PH35); Shaikh, Ikrar Abrarahmad (17DPH65)
    Many local Vaidya have been giving Edible lime for the treatment of jaundice and other liver diseases. Also, it is infamously consumed along with tobacco for ages. The purpose of this investigation was to determine lethal concentration 10 (LC10) and study the hepatoprotective activity of Edible lime on the zebrafish model. LC10 value of Edible lime was calculated by using probit analysis, and it was found to be 95.49 mg/L. Liver toxicity was induced in zebrafish larvae by using paracetamol. Liver atrophy, yolk sac retention, increase in optical density of liver, increased in the level of AST and ALT revealed paracetamol-induced liver toxicity in zebrafish larvae. The Edible lime showed a significant increase in liver size, and decrease in yolk sac retention, reduced liver degeneration, reduced AST and ALT level. The present study revealed the hepatoprotective activity of Edible lime.