Browsing by Author "Shaikh, Atif"

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    Novel approach to develop ciprofloxacin hcl buccal patches by using semisynthetic polymers: development, characterization, and antimicrobial efficiency
    (AIKTC, 2026-05) Shaikh, Atif; Momin, Jiyad (22PH49); Mirza, Roshin Jais (23DPH05); Patel Adeel (23DPH06); Muke, Saima Aslam (23DPH07); Shaikh, Ayesha Afzal (23DPH09)
    Ciprofloxacin HCL come under class fluoroquinolone antibiotic which are mostly used as infection generally gram positive and gram negative by inhibit the DNA gyrase of bacteria and topoisomerase. [1,2] Orally ingested ciprofloxacin HCL have some limitations that is gastrointestinal adverse effect, interaction between the food and drug, variable in absorption of drug of ciprofloxacin HCL and show reduction in the bioavailability due to first pass metabolism. Due to this reason ciprofloxacin HCL buccal film show prominent effect on therapeutic effect as compare to convectional dosage form. [3,4] Buccal drug delivery system shows effective alternative way as compare to orally administered drug and show the effective alternative route to show drug absorption in buccal region and also avoid first pass metabolism and hence improve its bioavailability. [6,7] There are more approaches of buccal delivery but the buccal film has shown more significance than ease of drug Administration of accurate dosing and increased patient compliance, prolonged residence duration at application sites. [8,10] Usage of polymer of ciprofloxacin HCL buccal film such as hydroxypropyl, methylcellulose, polypropylene, chitosan, and Carbopol facilitate control drug release and enhance mucosal adhesion. [11,12] Ciprofloxacin extensively used in treatment of respiratory tract infections, urinary tract infections, soft tissue infections, skin infections, and also bone and joint infections due to its broad-spectrum antimicrobial activity and strong Bactericidal effect. As compared to therapeutic effectiveness the conventional oral administration of ciprofloxacin HCl has shown several pharmacokinetic and pharmaceutical limitations that is gastrointestinal irritation, food drug interaction, drug absorption variability, and reduce systematic bioavailability of drug due to hepatic first pass metabolism. Because these limitations therapeutic effectiveness are reduced and required repeated dosing to maintain adequate plasma drug concentration Key Words- Ciprofloxacin HCl; Mucoadhesive buccal films; Buccal drug delivery system; Controlled drug release; Bioavailability enhancement; Hydroxypropyl methylcellulose (HPMC); Polyvinylpyrrolidone (PVP); Antimicrobial activity.