Browsing by Author "Shaikh, Saba"

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    Comparative study of anti-inflammatory activity of aqueous and methanolic extracts of hibiscus cannabinus leaf (Malvaceae)
    (International Journal of Pharmacy and Pharmaceutical Sciences, 2016-04) Shaikh, Saba
    Objective: The present study was undertaken to investigate and compare the anti-inflammatory activity of an aqueous and methanolic extract of Hibiscus cannabinus (Malvaceae) using carrageenan-induced rat paw edema. Methods: Aqueous and methanolic extracts of Hibiscus cannabinus was prepared and tested for anti-inflammatory activity in female spargue dawley rat weighing 150-180 g. The animals were randomly divided into 6 groups of 6 each. First group served as vehicle control, second group served as standard, third and fourth group served as high (400 mg/kg) and low (200 mg/kg) dose of methanolic extract of Hibiscus cannabinus leaves (MHCL) respectively and fifth and sixth group as high (400 mg/kg) and low (200 mg/kg) dose of aqueous extract of Hibiscus cannabinus leaves (AHCL) respectively. The In vivo anti-inflammatory activity was studied using carrageenan induce rat paw edema animal model. The estimation of liver and blood parameters consist of serum glutamic oxalate transaminase (SGOT), serum glutamic pyruvate transaminase (SGPT), lipid peroxidation (LPO), reduced glutathione (GSH) and superoxide dismutase (SOD). Results: Both MHCL and AHCL extracts showed significant (*p<0.05) inhibition of rat paw edema in dose-dependent manner. The maximum percent inhibition in paw edema was found in MHCL at dose of 400 mg/kg was 52.00% and AHCL at dose of 400 mg/kg was 49.93%. Both MHCL and AHCL at dose of 400 mg/kg reduce LPO level as 31.10 nmol/g and 35.23 nmol/g respectively when compared with standard indomethacin. Conclusion: An anti-inflammatory activity was found in both MHCL and AHCL extracts. But the MHCL showed more significant anti-inflammatory activity.
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    Covid-19 and its impact on mental health
    (AIKTC, 2021-05) Shaikh, Saba; Shah, Abdul Hafiz (17PH43); Shaikh, Asma (17PH47); Bhat, Tawfeeq anwar (17PH60); Khan, Adil (18DPH03)
    Coronavirus disease (COVID-19) is an infectious disease caused by a newly discovered coronavirus. (1) A coronavirus is a kind of common virus that causes an infection in your nose, sinuses, or upper throat. Most coronaviruses aren't dangerous. In early 2020, after a December 2019 outbreak in China, the World Health Organization identified SARS-CoV-2 as a new type of coronavirus. The outbreak quickly spread around the world. COVID-19 is a disease caused by SARS-CoV-2 that can trigger what doctors call a respiratory tract infection. It can affect your upper respiratory tract (sinuses, nose, and throat) or lower respiratory tract (windpipe and lungs). It spreads the same way other coronaviruses do, mainly through person-to-person contact. Infections range from mild to deadly. SARS-CoV-2 is one of seven types of coronavirus, including the ones that cause severe diseases like Middle East respiratory syndrome (MERS) and sudden acute respiratory syndrome (SARS). The other coronaviruses cause most of the colds that affect us during the year but aren’t a serious threat for otherwise healthy people.
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    Formulation and evaluation of antimicrobial activity of polyherb gel
    (AIKTC, 2020-05) Shaikh, Saba; Sarguru, Rimsha Abdul Shakoor (16PH42); Shaikh, Munazza Mohammad Irfan (16PH54); Hawai, Owais (15PH09)
    The practice of herbal medicine has existed since prehistoric times as the primary form of medicine. In this space age where the technology has very much advanced, herbal medicines still flourish and are finding exceptional acceptance in both the developing and the developed countries due to their natural origin and lesser side effects. Besides widespread use of botanicals as medicinal products in developing countries, such products are fast becoming a part of the integrative healthcare systems of the industrialized nations, known as complementary and alternative systems of medicine. A number of herbal traditions have come to dominate the practice of alternative medicine. These include the western herbal tradition based on Greek, Roman and medieval sources, the essentially Ayurvedic tradition of India and the Chinese herbal medicine. The traditional Chinese medicine continues as a distinct branch of modern medical practice .The traditional herbal remedies as alternative medicine plays a significant role in South Africa also, where it forms a part of the culture and beliefs of the indigenous population and also features significantly in primary health care. Botanicals or phytomedicines have always been a major component of traditional systems of healing in developing countries, which have also been an integral part of their history and culture. In the ancient Indian system of medicine, Ayurveda and Siddha are such examples [1].
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    Hepatoprotective activity of the formulated tablet in zebrafish
    (AIKTC, 2022-05) Shaikh, Saba; Khan, Ashraf Wahid (18PH32); Khan, Naziya Tarannum (18PH40); Khan, Zainab Riyaz (18PH45); Momin, Shifa Irshad (18PH49)
    In this new era of drug development, the most of the drugs which are Emerging in the market are synthetic one, having a variety of adverse Effects on different body organs mainly on liver. Since These drugs are synthetically prepared they have a high market price, to Overcome such difficulties there is the need for a substance that is Efficacious and abundantly available. The traditional medicine all across the world is Praised due to extensive activity of research on plant species and their therapeutic effect. When a formulation contains two or more herbs then the formulation is known as polyherbal formulation’. Nowadays, a large number of population suffers from disease related to liver for which the cause is unknown. So the development of hepatoprotective drug having huge demand has drawn the attention of researchers to formulate a herbal formulation with no side effects, as the synthetic drugs itself leads to various toxicity problems. The present study was aimed to formulate a polyherbal Tablet having antihepatotoxic effect and analysis of tablet is done by invivo. Our scientific research-based study has been planned on the zebrafish Model, as zebrafish embryos are transparent it allows study of internal organs [3]. Zebrafishes are mostly used as an in-vivo model for the screening of drugs because of its rapid organogenesis.
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    Synergistic effect of polyherbal extract for Anti-melanogenic activity in zebrafish (danio rerio)
    (AIKTC, 2022-05) Shaikh, Saba; Inamdar, Shoaib isak (18PH25); Khan, Saniya Siraj (18PH42); Rakhe, Nameerah Salman (18PH53); Parab, Trupti Vidyadhar (18PH55)
    The most prevalent source of skin damage is UV radiation, which causes cancer, sunburns, and dark patches and hyperpigmentation . Despite the availability of synthetic skin whitening treatments, the desire for natural or herbal formulations has opened a new path for the cosmeceutical sector owing to their property of having fewer side effects. The purpose of this research study is to evaluate the preliminary properties of herbal extracts of Glycyrrhiza glabra and Citrus aurantium Lin. , determination and evaluation of MNLC, Lethal Dose 50 (LD50) using probit analysis and finally study the anti melanogenic activity of the herbal extracts including determination of synergistic activity. The LD 50 value was calculated as 34.7 ppm and 56.23ppm for OP and LQ respectively by probit analysis and anti melanogenic activity was determined by Image J software. The study report showed an increase in mortality and decrease in hatchability with the increase in dose of the herbal extract. The anti-melanogenic studies indicated decrease in integrated density with increased concentration in comparison with standard and PTU.