SYNTHESIS AND ANXIOLYTIC ACTIVITY OF 2-METHYL-3-AMINO-4- QUINAZOLINONE ACETAMIDE DERIVATIVES
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Date
2014
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Coden HLEEAI
Abstract
Medicinal Chemistry plays a vital role in the eradication of fatal diseases in human being. Quinazolin-4-one is versatile lead molecule. The synthesis of its derivatives has been the focus of great interest for the development of newer bioactive agent. The present study involves the synthesis, purification and characterisation of various acetamide derivatives of 3-aminoquinazolinone. Methyl Anthranilate on condensation with acetic anhydride in presence of pyridine and hydrazine hydrate form 2-methyl-3-amino-4-quinazolinone. The purity of synthesized compound was checked by Thin Layer Chromatography. The melting point of synthesized compounds were analysed with an open ended capillary tube method. Structures of synthesized compounds were elucidated by FT-IR, GC-MS, and NMR spectral analysis. The synthesized compounds were evaluated for anxiolytic activity by Elevated plus Maze Test and Light and Dark Test using Diazepam as standard.
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Staff Publication - SoP
Citation
Vol. 4: (2), 2014, 363-370