Formulation and evaluation of transfersomal cream of Acriflavin

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dc.contributor.authorGaikwad, Madhuri
dc.date.accessioned2019-04-08T11:01:05Z
dc.date.available2019-04-08T11:01:05Z
dc.date.issued2016-09
dc.description.abstractA burn can be major medical problems or life threatening emergencies admitted to any hospital. Conventional topical burn formulations are required to be applied 3 to 4 times a day and previous application is needed to be removed prior to application of each new dose which is very painful to burn patients. In this research an attempt was made to increase the patient compliance by reducing the dosing frequency through sustained released vesicular drug delivery system like transfersomes. Transfersomes were formulated using by thin film hydration method and evaluated for entrapment efficiency, photo microscopy, scanning electron microscopy, vesicle size, poly dispersity and zeta potential. optimized transfersomal batch was incorporated in cream base and evaluated for pH, spread ability, viscosity, grud contyent and in-vitro diffusion. Transfersomes prepared by using 1:3 ratio of Sodium cholate with cholesterol and 200 mg drug showed highest entrapment(91.65%) and sustained release(65.18% in was 24 hrs.)was obtained with transfersomal cream in comparison with conventional formulation(97.54%) in 8 hrs.en_US
dc.identifier.issn2230-8407
dc.identifier.urihttp://www.aiktcdspace.org:8080/jspui/handle/123456789/2900
dc.language.isoenen_US
dc.publisherInternational Research Journal Of Pharmacyen_US
dc.relation.ispartofseriesVol.7;Issue 8
dc.subjectStaff Publication - SoPen_US
dc.titleFormulation and evaluation of transfersomal cream of Acriflavinen_US
dc.typeArticleen_US
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