Nanofiber reinforced hydrogel patch for cosmetic scar management
| dc.contributor.author | Gaikwad, Madhuri | |
| dc.contributor.author | Saloni, Nandkumar Ghanekar (22PH17) | |
| dc.contributor.author | Kunal Ramchandra Gupta (22PH18) | |
| dc.contributor.author | Sherebano, Moiz Najmee (22PH54) | |
| dc.contributor.author | Jasmine A Razzak Parkar (22PH57) | |
| dc.contributor.author | Pathan, Almas Mohin (22PH58) | |
| dc.date.accessioned | 2026-07-03T05:44:57Z | |
| dc.date.available | 2026-07-03T05:44:57Z | |
| dc.date.issued | 2026-06 | |
| dc.description.abstract | This study displays the development and evaluation of a biomimetic nanofiber-reinforced hydrogel patch tailored for the cosmetic management of hypertrophic scars and keloids. The composite patch mimics the skin's natural extracellular matrix using an electrospun polyvinyl alcohol (PVA) nanofiber layer and a sodium alginate-gelatinee hydrogel base. It co-delivers tranexamic acid within the hydrogel to target hyperpigmentation and copper tripeptide-1 embedded in the nanofibers to promote organized collagen remodelling. Physicochemical evaluations revealed a skin-compatible pH of 5.5, high swelling capacity for optimal moisture retention, and an 83.55% gel fraction ensuring structural durability. Scanning electron microscopy confirmed a uniform, bead-free nanofiber network, while FTIR analysis validated the chemical stability and successful loading of the active ingredients. In vitro studies demonstrated a controlled, sustained biphasic drug release profile and verified antimicrobial efficacy against Staphylococcus aureus. The dual-drug composite system successfully provides a safe, structurally robust, and biomimetic platform for accelerated tissue regeneration and scar reduction. Keywords Nanofiber-reinforced hydrogel, Scar management, Electrospinning, Tranexamic acid, Copper tripeptide-1, Biomimetic patch, Sustained drug delivery. | |
| dc.identifier.uri | http://aiktc.ndl.gov.in/handle/123456789/4537 | |
| dc.language.iso | en | |
| dc.publisher | AIKTC | |
| dc.title | Nanofiber reinforced hydrogel patch for cosmetic scar management | |
| dc.type | Project Report |