School of Pharmacy - Project Reports

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Teratogenic and hepatoprotective activity of edible lime using the zebrafish model
(AIKTC, 2020-05) Shaikh, AbuSufiyan S.; Balabhai, Iqra Zahid (16PH06); Gupta, Shubham Suresh (16PH17); Pathan, Muskan Mohin (16PH35); Shaikh, Ikrar Abrarahmad (17DPH65)
Many local Vaidya have been giving Edible lime for the treatment of jaundice and other liver diseases. Also, it is infamously consumed along with tobacco for ages. The purpose of this investigation was to determine lethal concentration 10 (LC10) and study the hepatoprotective activity of Edible lime on the zebrafish model. LC10 value of Edible lime was calculated by using probit analysis, and it was found to be 95.49 mg/L. Liver toxicity was induced in zebrafish larvae by using paracetamol. Liver atrophy, yolk sac retention, increase in optical density of liver, increased in the level of AST and ALT revealed paracetamol-induced liver toxicity in zebrafish larvae. The Edible lime showed a significant increase in liver size, and decrease in yolk sac retention, reduced liver degeneration, reduced AST and ALT level. The present study revealed the hepatoprotective activity of Edible lime.
HPLC analysis of avanafil- An overview
(AIKTC, 2022-05) Sheikh, Imran; Shaikh, Abukais Mohammed (18PH65); Shaikh, Mohammed Tehran (18PH75); Shaikh, Mohammed Sufiyan (18PH76); Khan, Raza (18PH39)
Medical product design, development, standardisation, and quality control all rely on analytical techniques. They play an equal role in pharmacokinetics and drug metabolism research. Both of these factors are critical in determining bioavailability.the length of the clinical response In the field of analysis, analytical instrumentation plays a crucial role.creation and evaluation of new items, as well as consumer production and evaluationenvironment.The key to the design, development, and implementation of highly specific sensitive analytical procedures is the use of highly specific sensitive analytical techniques.
Magnetic nanoparticles embedded hydrogel for Wound healing
(AIKTC, 2022-05) Murugesan, Arulselvan; Qureshi, Souleha (18PH57); Shaikh, Darakshan (18PH67); Shaikh, Rubina Banu (18PH79); Shaikh, Saima (18PH80)
Our past few decades nanoparticles showed promising scope in the field of biomedical science in cancer treatment. Iron based nano particles MNPs mostly investigated since its role in drug delivery identified nanotechnology has gained attention of many researchers as they have unique magnetic property with size range of nano that proves to be helpful for drug delivery.
Study of teratogenic effect of erythromycin during embryonic development in zebrafish (danio rerio)
(AIKTC, 2022-05) Shaikh, AbuSufiyan S.; Ansari, Mohd Aftab Md. Ashfaque (18PH04); Gupta, Roma (18PH21); Khan, Abdul Razzaque (18PH29); Khan, Humera Aleem (18PH35)
Humans have developed many medications for their safety and for improving their quality of life. Among all the different medications antibiotics are most commonly prescribed in every disease state. Teratogenic and toxicity studies of different antibiotics to date have demonstrated significant effects in both animal models and clinical studies. The purpose of this investigation was to determine lethal concentration 10 (LC10), hatchability, mortality, and heart rate and study the teratogenic effect and toxicity of Erythromycin in the zebrafish model. Probit analysis is used to calculate LC10 value , and it was found to be 44.66 mg/L. In the case of Erythromycin hatchability decreases with increasing dose, mortality increases with increasing dose, and heart rate decreases with increasing dose. However, no effect was observed on the morphological characteristics in developing embryos of zebrafish larvae. This research can be used in considering the safety of Erythromycin for their use during pregnancy.
Comparative teratogenic and anticonvulsant activity of phenytoin and unani herbal formulation habbe sara in zebrafish (danio rerio)
(AIKTC, 2022-05) Shaikh, AbuSufiyan S.; Chorage, Aditi Uttam (18PH16); Falke, Mehreen Mushtaque (18PH20); Kesharvani, Kajal Tulshiram (18PH27); Nair, Akhil Anil (18PH62); Wadkar, Adnan Iqbal (18PH98)
Evaluation of multifacet role of biowaste for pharmaceutical and cosmetic purpose
(AIKTC, 2022-05) Lal, Mariya; Samant, Vedant Bipin (18PH61); Kazi, Nida Imtiyaz (18PH26); Shaikh, Abusaleh Abdulwadood (17PH45); Khan, Ajmat MD. Ali (18PH31); Qureshi, Arbaaz Ilahi (16PH38)
Now a days there are various materials which are obtained which contains chemicals and various inorganic matter which at times causes harm to the people when in use. Hence to overcome this problem we selected a material known as date seed powder which showed number of properties in all aspects. The absorbing properties of the date seed powder made us understand its role as a very powerful adsorbent for various practical aspects. The phytochemical screening which was performed showed us the exact estimation of the pigments that are present in the date seed powder. The stability studies and the coloring properties of the date seed powder helped us to understand the importance and the use of the natural pigments which were present in the biowaste pit. The formulation aspect of the face wash formulation depicted skin soothing effect with less chemicals as compared to tar based charcoal products in market and would cause less irritation to the skin and provide a soothing effect to the skin.
Preparation & evaluation of herbal formulation- lip balm using sapodilla fruit extract
(AIKTC, 2022-05) Sayed, Ajaz Ahmad; Mukadam, Sarbaz Ashfaque (18PH50); Khan, Nurullah (18PH41); Khan, Subhan (18PH43); Shaikh, Yashfeen Yunus (18PH86); Siddiqui, Muskan Salim (18PH95)
Design, formulation and quality improvement of Lip Balm made from herbal ingredients with consideration to use of Natural Antioxidants replacing chemical based anti-oxidants present in the current lip care product market. With the help of available studies and literature available and selecting Sapota as the key ingredient towards the formulation of Lip Balm and its antioxidant activity. Among the different types of fruit extract sapodilla extract shows good levels of Anti-Oxidant activity which can be used in the formulation of completely nature-based products, also it is inexpensive, easily available and bio-degradable. Sapota Powder can be used as alternative to Anti-oxidants in various herbal formulations which can also be profitable to the farmers. Post formulation studies helped to evaluate the optimum results for pH, Irritation Test, chemical stability proved to be a formation of stable herbal product.
Transdermal gel embedded with medicated solid lipid nanoparticles (sln’s)”
(AIKTC, 2022-05) Baig, mirza Salman; Hajwani, Amina Sajjad Mehtab (18PH22); Khan, Afreen Afaque (18PH30); Ansari, Md. Numan Shaikh Ismail (19DPH02); Zerdi, Nazir Ahmed Iqbal Ahmed (19DPH10)
Rheumatoid/Osteoarthritis is one of the most common causes for lacking behind in the health sector. Medication in the form of tablets is already available in the market but has disadvantages like: when taken orally as it reacts with the stomach acidic pH causing heartburn and belching and patients with existing liver disease suffer more with NSAIDs used for RA. Introduction of the Transdermal drug delivery system over the last few decades have changed the perspective of the prescriber and also the patient’s compliance is well taken care of. Here, in this study the transdermal drug delivery system in accordance with Nanoparticles with Solid Lipid as carrier with surfactant/polymer and drug used in Arthritis. INDOMETHACIN is clearly observed and studied for further evaluation. Studies also show that drugs like Indomethacin and Estradiol, when studied in rat models, were able to be enhanced when incorporated into Nanoparticles. Method by which the entire study was performed was with the help of Probe Sonicator that works on the principle of high intensity ultrasound waves to break bigger particle agglomerates into smaller ones. Suitable methods are HIGH PRESSURE HOMOGENISER and SOLVENT EVAPORATION METHOD. With High pressure homogeniser, problems such as low efficiency of product process were found out, but with Solvent Evaporation method, the sonication process went easily. Evaluation parameters of nanoparticles formulation are: 1) Particle Size Determination by Zetasizer as an instrument 2) Gel formulations are pH determination, Spreading coefficient, Viscosity, Visual appearance & Clarity.
Formulation and evaluation of solid dispersion incorporated oro-dispersible tablet
(AIKTC, 2022-05) Baig, Mirza Anwar
Indomethacin is a Non-Steroidal Anti-Inflammatory (NSAID) drug that is used in the treatments of osteoarthritis, bursitis, tendinitis, rheumatoid arthritis, gout, ankylosing spondylitis, and headaches. Indomethacin has a short and unpredictable oral bioavailability due to the drug's poor solubility in the gastrointestinal tract's fluids (GIT) To enhance the aqueous solubility of insoluble drug, polymeric carriers have been used. The investigation of this study was to formulating, evaluating and characterizing solid dispersion of Indomethacin with PEG 6000 and PVP K30 for increasing its dissolution rate and bioavailability. The solid dispersion was formulated by kneading method. The solid dispersion were characterized by Fourier transform infrared spectroscopy. The powder blend were evaluated for pre-compressional studies like bulk density, tapped density, carr’s compressibility index, Hausner ratio and post compressional studies like hardness, friability, wetting time, dissolution test. All the pre and post compressional parameters evaluated were within the pharmacopoeial limits. Indomethacin spectra shows a prominent peak at 320nm which indicates trace amount of methanol did not interfere in absorption. It was concluded that range of absorption lies in ranges of 0.1 to 0.4 and hence it follows beer lambert law. The r² value was found to be 0.9952. From the result it is concluded that Oro-dispersible tablets of poorly soluble drug, Indomethacin showed increased dissolution and thus enhanced bioavailability, improved efficacy and improved patient compliance.
Synergistic effect of polyherbal extract for Anti-melanogenic activity in zebrafish (danio rerio)
(AIKTC, 2022-05) Shaikh, Saba; Inamdar, Shoaib isak (18PH25); Khan, Saniya Siraj (18PH42); Rakhe, Nameerah Salman (18PH53); Parab, Trupti Vidyadhar (18PH55)
The most prevalent source of skin damage is UV radiation, which causes cancer, sunburns, and dark patches and hyperpigmentation . Despite the availability of synthetic skin whitening treatments, the desire for natural or herbal formulations has opened a new path for the cosmeceutical sector owing to their property of having fewer side effects. The purpose of this research study is to evaluate the preliminary properties of herbal extracts of Glycyrrhiza glabra and Citrus aurantium Lin. , determination and evaluation of MNLC, Lethal Dose 50 (LD50) using probit analysis and finally study the anti melanogenic activity of the herbal extracts including determination of synergistic activity. The LD 50 value was calculated as 34.7 ppm and 56.23ppm for OP and LQ respectively by probit analysis and anti melanogenic activity was determined by Image J software. The study report showed an increase in mortality and decrease in hatchability with the increase in dose of the herbal extract. The anti-melanogenic studies indicated decrease in integrated density with increased concentration in comparison with standard and PTU.
Hepatoprotective activity of the formulated tablet in zebrafish
(AIKTC, 2022-05) Shaikh, Saba; Khan, Ashraf Wahid (18PH32); Khan, Naziya Tarannum (18PH40); Khan, Zainab Riyaz (18PH45); Momin, Shifa Irshad (18PH49)
In this new era of drug development, the most of the drugs which are Emerging in the market are synthetic one, having a variety of adverse Effects on different body organs mainly on liver. Since These drugs are synthetically prepared they have a high market price, to Overcome such difficulties there is the need for a substance that is Efficacious and abundantly available. The traditional medicine all across the world is Praised due to extensive activity of research on plant species and their therapeutic effect. When a formulation contains two or more herbs then the formulation is known as polyherbal formulation’. Nowadays, a large number of population suffers from disease related to liver for which the cause is unknown. So the development of hepatoprotective drug having huge demand has drawn the attention of researchers to formulate a herbal formulation with no side effects, as the synthetic drugs itself leads to various toxicity problems. The present study was aimed to formulate a polyherbal Tablet having antihepatotoxic effect and analysis of tablet is done by invivo. Our scientific research-based study has been planned on the zebrafish Model, as zebrafish embryos are transparent it allows study of internal organs [3]. Zebrafishes are mostly used as an in-vivo model for the screening of drugs because of its rapid organogenesis.
Evaluation of quality control parameters for expired and non-expired chloroquine phosphate tablet (lariago 250mg) ip
(AIKTC, 2022-05) Nikhat, Farhana; Reshma, Y.; Chaudhary, Abdul Wahid (18PH12); Hamdulay, Ilaf Dawood (18PH23); Khan, Mohd Emad (18PH34); Khan, Junaid Emtiyaz (18PH36)
This study aimed to compare the different quality control parameters for expired and non-expired Chloroquine Phosphate tablet formulations. An expiration date, typically labeled by the manufacturer, refers to the time period during which the product is expected to retain its stability, or retain its quality, strength, and purity, when it is stored appropriately according to its labeled storage conditions. In some cases, some study reveals that, if the medicinal products are stored properly it is possible that they can retain stability even beyond their expiration date and are assumed safe to use. While it is important to ensure patient safety, the study is expected to focus on the quality of expired drug and to assess whether the quality of expired medicine deteriorates to what extent. It will also help in understanding potency of the expired formulation after the date of expiry and what are parameters which are affected after expiry date. This work focuses on qualitative evaluation of expired formulation with respect to the non-expired one. The results of this investigation can be utilized to help prepare for public health emergencies (for example, during a terrorist attack, in a war, outbreak of viral-flu, epidemic, pandemic, or earthquake) or drug shortages occurring due to many reasons including manufacturing and quality problems, delays, and discontinuations severe enough to cause local medical supplies to run out.
Phytochemical and pharmacological screening of cissus quadrangularis for anti-gout activity
(AIKTC, 2022-05) Nikhat, Farhana; Reshma, Y.; Ansari, Md. Naved (18PH02); Ansari, Md. Zahid (18PH03); Ansari, Shahabuddin S. (18PH07); Idrisi, Saddam Husain (18PH24)
Gout is a common rheumatic diseas with a pathological basis of hyperuricemia, which occurs when uric acid level in the blood surpass 390mol/L or 6.5 mg/dL, resulting in the development of monosodium urate (MSU) crystal in various tissues, particularly in the joints.
Extraction of natural starch and preparation of paracetamol tablets
(AIKTC, 2022-05) Rehan, Abdur Rub; Vyawahare, Maithili Pravin (18PH97); Chaudhary, Sahid Abdul Samad (18PH14); Shinde, Snehal Vinod (18PH90); Momin, Md Anas Sabir (16PH31)
Starch has many roles in formation studies blooming in today's time. We can extract starch from various sources and ways accordingly.
Stimuli responsive polymeric carriers for target delivery of antiacne agent: novel drug design to reduce the drug related side effect
(AIKTC, 2022-05) Rehan, Abdur Rub; Shaikh, Shifa Ashfaque (18PH83); Shilar, Shafiya Tanzil (18PH88); Sayyed, Amir Aslam (18PH63); Mohd Salman, Riyazuddin (17PH33)
Characteristicso of acne skin is that is possesses relatively lower pH microenvironment as compare to healthy skin, salicylic acid is belonging to the class of medication called as keratolytic agent.
Green synthesis of dihydropyrimidinone using solvent free grinding method
(AIKTC, 2022-05) Patil, Jayshree; Sontakke, Anjali (19DPH01); Shaikh, Rushda (19DPH06); Shaikh, Shahbaz (19DPH07); Siddiqui, Kamil (19DPH09); Khan, Tahzeeb (18PH44)
A facile protocol for one pot (Multicomponent) synthesis of Pyrimidinone derivative through Beginelli reaction by completely different inexperienced ways like heating without catalyst, grinding within the presence of catalyst Cerric nitrate (CAN) and ammonium chloride (NH4Cl) has been performed. The reaction has been continuing smoothly below solvent free condition on grinding of mixture of various organic compound i.e Benzaldehyde, ethyl acetoacetate and urea during a mortar. Dihydropyrimidinone area unit the vital bioactive heterocyclic compounds, this has established an attention in revising the new drug entities based mostly upon the dihydropyrimidinone activity. Its intercalary importance in Pharmaceutical and medicative field thanks to its broad biological activities. The analysis is performed and compared for synthesized product exploitation completely different inexperienced ways. It's been additionally screened for antibacterial drug activity. On comparison, it's been found that grinding technique is a smaller amount time intense as compared to heating and was command while not generating any pollution in quicker time interval, safe to analyst and easy to handle. The good thing about this new protocol lies in avoiding the organic solvent, varied substrate, use low-cost or cheap catalyst that all contributes to safer chemistry.
Synthesis and characterization of eco-friendly bioplastic
(AIKTC, 2022-05) Patil, Jayshree; Ansari, Mohammed Asim Hafiz Tahir (18PH01); Shaikh, Mohammad Kashif Faizan Ahmad (18PH37); Malik, Adil Aziz (18PH46); Malik, Asheya Sadeeq (18PH47); Shaikh, Mohd Raheel Abdulwaris (18PH78)
Petrochemical based plastics are already recognized for its practice in entirely packaging industries, but petrochemical plastics produces harmful environmental issues, as its very challenging for its degradation in the environment. To minimize the detrimental effects on nature, petrochemical plastic must be replaced by bioplastic. Bioplastic is obtained from many sources such as starch-based Bioplastic, Cellulose based Bioplastic, Protein-based Bioplastic, and Aliphatic polyesters bioplastics. The making of biodegradable plastics with edible polysaccharides is economic and safe and it will definitely assist in the reduction of environmental disasters. Bioplastic can be the best substitute for conventional plastic in the diverse segments such as food packing plastic dishes of cutlery plastic, packing bags, storing flask etc. Currently biobased polymers are usually found in numerous utilization from commodity to hi-tech applications due to development in biotechnology and public awareness. The present study offers a biodegradable plastic made from tamarind seed powder. The product of the current plan has extensive industrial practices e.g. in manufacture of biodegradable art objects/household items, carry bags, wrapping/packing material etc. and also biomedical arena e.g. dressings, sutures.
Transdermal spray forpsoriasis treatment
(AIKTC, 2022-05) Murugesan, Arulselvan; Siddiqui, Iqra Nadim (18PH93); Shikalgar, Azim Akhtar (18PH87); Shinde, Sagar Shashikant (18PH89); Shaikh, Mohd. Altaf (18PH77)
Psoriasis is a chronic autoimmune disorder and it is characterized by raised thick, red patches that are covered with a silvery layer of dead skin cells.
Evaluation of invitro antidiabetic, antibacterial and Antioxidant effect of phenolic acid
(AIKTC, 2022-05) Baig, Mirza Anwar; Shaikh, Juned Mohd Jamil (18PH70); Shaikh, Sufreen Banu Abdul Rehman (18PH84); Siddiqui, Murshida Bakar Husain (18PH94); Shaikh Bushra, Firdous Mohammed Asif (19DPH03)
The in-vitro evaluation of antidiabetic, antibacterial, antioxidant activity of caffeic acid was investigated. α amylase inhibition was measured as it is a key enzyme in carbohydrate metabolism. Antioxidant effect was measured by hydroxyl radical scavenging and DPPH method. For antibacterial activity agar well diffusion method was used and staphylococcus aureus was cultured to test it. Caffeic acid significantly inhibited α amylase, DPPH, hydroxy radical scavenging activity. The current study proves that the caffeic acid showed significant antidiabetic, antibacterial and antioxidant effects in vitro studies.
Knowledge, attitude, practice of pharmacovigilance Amongst medical practitioners, pharmacy faculties and students in Navi mumbai
(AIKTC, 2022-05) Baig, Mirza Anwar; Shaikh, Irfan Mohammed Hanif (18PH69); Shaikh, Saima Shahid (18ph81); Shaikh, Sarfaraj Ahmed Athar Hussain (18PH82); Siddiqui, Farhaan Mohammed Ameen (18ph91)
It is an important factor to report an adverse drug reaction (ADR) in pharmacovigilance, this study is planned to assess the knowledge, attitude, and practice (KAP) of pharmacovigilance in pharmacy students, faculty, and doctors and the pattern of reporting system of adverse drug reaction. Design and Methods: A cross-sectional study was done over six months that uses questionnaires to evaluate the KAP of pharmacovigilance. A sample size of 700 was selected using a 95% confidence level with the raosoft online sample size calculator. A sampling method was used to select students, faculty of pharmacy, and doctors in Navi Mumbai from different departments. Data was analyzed with the SPSS 20, Tableau software for graphical evaluation, and Microsoft excel. The mean standard deviation was determined with P< 0.05 and was regulated between two attributes. Result: 427 responses were received from 700 distributed questionnaires, giving a 57% response rate. Most students who participated with 88.70% (n=291) are less than equal to 25 years old. Faculty between the ages of 25-34 responded 70.20% (n=33). Doctors less than 25 with 40.00% (n=41) and between 25-34 participated 54.30% (n=19). Conclusion: Students show a good knowledge of pharmacovigilance and adverse drug reaction reporting, although their attitude and barrier was limited. faculty showed less attitude toward reporting as compared to doctor and student. Doctors have limited KAP in PV. This study provides an insight problem in PV and there needs to be improvement with an awareness program.

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