Green synthesis and characterization of bioactive quinazolinone schiff base
| dc.contributor.author | Patil, Jayshree | |
| dc.contributor.author | Shaikh, Heena Babu (16PH49) | |
| dc.contributor.author | Satpute, Swati Kulbhushan (16PH43) | |
| dc.contributor.author | Bhoir, Rahul Praod (16PH10) | |
| dc.contributor.author | Pathan, Shahabaz Abdul Wahab (16PH47) | |
| dc.date.accessioned | 2021-11-12T05:05:00Z | |
| dc.date.available | 2021-11-12T05:05:00Z | |
| dc.date.issued | 2020-05 | |
| dc.description.abstract | Schiff bases have gained importance in medicinal and pharmaceutical fields due to a broad spectrum of biological activities and have been utilized as synthons in the preparation of a number of industrial and biologically active compounds. Quinazolines and quinazolinones are medicinally important nitrogen hetero cyclic compounds. The combination of unique structural features, extensive functionalization, and very high biological activity found, both building blocks are tethered together to synthesize new chemical entity (NCE) 3- (benzylideneamino)-2-methyl-quinazolin-4-one, i.e. schiff base using lemon juice as green solvent. Utilization of fruit juices as a natural and biocatalyst permits mild and highly selective transformation and synthesis in a simplistic and environmentally friendly manner. The present synthesis proceeds via synthesis of Methyl-2- acetamidobenzoate from methyl anthranilate followed by cyclization to produce 3-amino-2-methyl quinazolin-4-one which on treament with benzaldehyde produces schiff base.The synthesized product was identified by its physical properties, melting point, TLC, FTIR and characterized by NMR. It is screened for antibacterial and antioxidant properties. Compared with traditional methods, this green method was more convenient and held without generation of pollution in shorter reaction time, safer to analyst, low cost and simple to run. Keywords: Schiff base, Quinazolinone, fruit juice, bio catalyst | en_US |
| dc.identifier.uri | http://localhost:8080/xmlui/handle/123456789/3682 | |
| dc.language.iso | en | en_US |
| dc.publisher | AIKTC | en_US |
| dc.subject | Project Report - SoP | en_US |
| dc.title | Green synthesis and characterization of bioactive quinazolinone schiff base | en_US |
| dc.type | Project Report | en_US |