Network pharmacology approach to study bryophyllum pinnatum in urolithiasis
| dc.contributor.author | Ziyaul Haque | |
| dc.contributor.author | Dalvi, Iqra Nadeem (22PH09) | |
| dc.contributor.author | Deshmukh, Khadija Juned (22PH12) | |
| dc.contributor.author | Khan, Tahreem Firoj Asgari (22PH42) | |
| dc.contributor.author | Qureshi, Misba Farooque (22PH59) | |
| dc.contributor.author | Shaikh, Rehana Md Ibrahim (22PH91) | |
| dc.date.accessioned | 2026-07-03T05:09:47Z | |
| dc.date.available | 2026-07-03T05:09:47Z | |
| dc.date.issued | 2026-05 | |
| dc.description.abstract | ABSTRACT Urolithiasis, commonly referred to as kidney stone disease, represents one of the most prevalent and recurrent urological disorders worldwide, affecting approximately 10-15% of the global population. The condition is characterized by the formation of solid crystalline deposits within the urinary tract, arising from the supersaturation of minerals such as calcium, oxalate, and uric acid. Despite advances in surgical and pharmacological interventions, the high recurrence rate and associated morbidity necessitate the exploration of novel therapeutic strategies, particularly those derived from natural sources with established ethnopharmacological use. Bryophyllum pinnatum (Family: Crassulaceae), commonly known as Patthar Chatta or Kalanchoe pinnata, has been extensively employed in traditional medicine systems across Asia and Africa for the management of kidney stones and urinary disorders. However, the precise molecular mechanisms underlying its anti-urolithiatic activity remain incompletely characterized. The present study employed an integrated network pharmacology and molecular docking approach to systematically elucidate the multi-component, multi-target, and multi-pathway mechanisms of Bryophyllum pinnatum in urolithiasis. A total of 30 phytochemical constituents were retrieved from Dr. Duke's Phytochemical and Ethnobotanical Database, of which five compounds- Kaempferol (BP15), Quercetin (BP26), Beta-sitosterol (BP6), Alpha-amyrin (BP4), and Citric acid (BP9) were selected following drug-likeness screening based on Lipinski's Rule of Five using Swiss ADME. Potential molecular targets for each compound were predicted using Swiss Target Prediction, while disease-associated targets for urolithiasis were retrieved from Gene Cards. Overlapping targets between compound and disease target sets were identified through Venn diagram analysis, yielding compound-specific common target lists. Protein-protein interaction (PPI) networks were constructed using the STRING database and visualized in Cytoscape, with Quercetin emerging as the hub compound exhibiting the highest degree of connectivity. Pathway enrichment analysis via KEGG identified key biological pathways including Nitrogen metabolism, Estrogen signaling, Relaxin signaling, IL-17 signaling, Metabolic pathways, and Renal cell carcinoma as significantly enriched. | |
| dc.identifier.uri | http://aiktc.ndl.gov.in/handle/123456789/4534 | |
| dc.language.iso | en | |
| dc.publisher | AIKTC | |
| dc.title | Network pharmacology approach to study bryophyllum pinnatum in urolithiasis | |
| dc.type | Project Report |