Students Project Reports (UG)

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Anti-acne formulation
(AIKTC, 2020-05) Gaikwad, Madhuri; Khan, Maseera Banu Fazlur Rehman (16PH23); Quadri, Heena Kausar Mohammed Umer (16PH36); Khan, Uzma Khatoon Abdul Muttlib (16PH28); Khatib, Rahil Abdul Rauf (16PH29)
Acne often debuts during changes in hormonal level in pre-teens and also caused by the bacteria P. Acnes. The isolation of the herbal active principle and the determination of their structure, in order that they are synthesized or simply extracted more efficiently. Allopathy means modem scientific medicine which leads to adverse drug reaction as allopathic drugs are in chemical form. As Dr. Manoj Nesari joint adviser department of Ayush states that "there is rising trend towards Ayurveda". And the demand for herbal products world-wide has increased at an annual rate of 8%. Manjistha commonly knows as Rubia Cordifolia works on P. Acnes and its anthraquinone rich constitutent also contains anti-inflammatory, anti bacterial and anti-oxidant propety. The cream, gel and ointment formulations are prepared using alcoholic, water and alcoholic extract respectively. The formulations are characterized and evaluated on the basis of its organoleptic properties, pH values, viscosity measurement, spreadability, stress testing and determination of invitro anti-acne activity. The organoleptic properties shows that the formulations are cosmetically appealing. Cream was found to be oil soluble and pH values of formulations was found to be stable after 2 weeks. Viscosity was found to be 1500-2000 cp. Spreadability of formulations was found to be in range of 10-25 mm. Stress testing shows that the formulation has good shelf-life. And the antimicrobial activity is compared between cream, gel and ointment. Keywords Acne, P.acnes, herbal products, Manjistha, anti-inflammatory property, anti-bacterial property, anti-oxidant, property, gel, cream, ointment, anti-acne activity, anti-microbial activity.
Colour changing anti-acne face mask
(AIKTC, 2022-05) Patil, Bhagyashree; Ansari, Namira Salim (18PH06); Bubere, Umama Naeem (18PH11); Chougule, Madiha Abdul Majid (18PH18); Sain, Sabira Mohammed Salim (18PH59)
Skin is the organ that acts as a protective barrier between the organism and the external environment . The skin prevents dehydration and damage due to heat and maintains a constant temperature.
Comparative teratogenic and anticonvulsant activity of phenytoin and unani herbal formulation habbe sara in zebrafish (danio rerio)
(AIKTC, 2022-05) Shaikh, AbuSufiyan S.; Chorage, Aditi Uttam (18PH16); Falke, Mehreen Mushtaque (18PH20); Kesharvani, Kajal Tulshiram (18PH27); Nair, Akhil Anil (18PH62); Wadkar, Adnan Iqbal (18PH98)
Computer aided drug design, its success and limitation
(AIKTC, 2020-05) Ansari, Nikhat; Bengal, Gajanan Bhujangrao (17PH05); Dabir, Safa Rafique (17PH07); KArbari, Tuba Salim (17PH16); Sayyed, Gufran Ali Meer Ajagar Ali (17PH42)
Moderndrugdiscoveryischaracterizedbytheproductionofvastquantitiesofcompoundsand theneedtoexaminethesehugelibrariesinshortperiodsoftime Theneedtostore,manageandanalyzetheserapidlyincreasingresourceshasgivenrisetothe fieldknownascomputer-aideddrugdesign(CADD). CADDrepresentscomputationalmethodsandresourcesthatareusedtofacilitatethedesign anddiscoveryofnewtherapeuticsolutions. Digitalrepositories,containingdetailedinformationondrugsandotherusefulcompounds,are goldminesfortheStudyofchemicalreactionscapabilities.Designlibraries,withthepotentialto generatemolecularvariantsintheirentirety,allowtheselectionandsamplingofchemical compoundswithdiversecharacteristics. Structure-baseddrugdesignandligand-baseddrugdesign aretwomethodscommonlyusedincomputer-aideddrugdesign.Inthisarticle,wediscussthe theorybehindbothmethods,aswellas theirsuccessfulapplicationsandlimitations.
Cosmetico vigilance of skin lightening agents: Patient utilization pattern versus virtual need in Mumbai metropolitan region
(AIKTC, 2021-05) Lal, Maria; Pophlunkar, Mustapha Javeed (14PH33); Gabhrani, Mehandi Reza Shabbirali (17PH09); Logde, Arjuman Nazir (17PH30); Parveen Saima, Mohammad Gulam Gaus (17PH35)
The preference to have white skin has driven the skin lightening (SL) industry. This phenomenon was reflected in the domination of skin lightening products in Asian skincare market with 60 percent of sales. Skin lightening products are readily available from major cosmetics companies, from local convenience stores, and widely over the internet. These types of products are marketed as skin-evening creams, skin lighteners, skin brighteners, skin whiteners, skin tones, fading creams, or fairness creams.
Covid-19 and its impact on mental health
(AIKTC, 2021-05) Shaikh, Saba; Shah, Abdul Hafiz (17PH43); Shaikh, Asma (17PH47); Bhat, Tawfeeq anwar (17PH60); Khan, Adil (18DPH03)
Coronavirus disease (COVID-19) is an infectious disease caused by a newly discovered coronavirus. (1) A coronavirus is a kind of common virus that causes an infection in your nose, sinuses, or upper throat. Most coronaviruses aren't dangerous. In early 2020, after a December 2019 outbreak in China, the World Health Organization identified SARS-CoV-2 as a new type of coronavirus. The outbreak quickly spread around the world. COVID-19 is a disease caused by SARS-CoV-2 that can trigger what doctors call a respiratory tract infection. It can affect your upper respiratory tract (sinuses, nose, and throat) or lower respiratory tract (windpipe and lungs). It spreads the same way other coronaviruses do, mainly through person-to-person contact. Infections range from mild to deadly. SARS-CoV-2 is one of seven types of coronavirus, including the ones that cause severe diseases like Middle East respiratory syndrome (MERS) and sudden acute respiratory syndrome (SARS). The other coronaviruses cause most of the colds that affect us during the year but aren’t a serious threat for otherwise healthy people.
Evaluation of herbal formulation for diuretic activity in experimental animals
(AIKTC, 2020-05) Baig, Mirza Anwar; Bhosale, Monika Bandu (16PH11); Bhanushali, Hetal Rajesh (16PH09); Gaikwad, Abhijeet Siddheshwar (16PH16); Daud, Ibrahim Shaikh Shaukat (16PH14)
Objective: The present study was designed to evaluate the diuretic activity of herbal formulation (Gokhru Kadha). To investigate/propose probable mechanism of action of herbal formulation. Method: Animals were divided into 5 groups of 6 Swiss mice each. Group 1 served as control and administered with vehicle. Groups II, III and IV: Served as treatment group and a single dose of 20 mg, 40 mg and 60 mg/kg of HF administered orally to group II, III and IV respectively. Group V: Served as standard, treated with furosemide (10 mg/kg), and dissolved in 0.9% normal saline with CMC. Two days prior to experiments, mice were kept in metabolic cages with free access to food and water for acclimatization. Four hours before testing, the animals were fasted, with free access to drinking water only. All animals were given an oral loading of normal saline (5% by wt.). For Acute- Freshly prepared doses of test and standard drug were administered to test and standard animal group respectively. Immediately after dosing, animals were kept in metabolic cages for 6 hours and finally urine was collected, measured and filtered at the end of 6 hours 8 for various biochemical estimations. For Chronic- Daily doses of test and standard drugs were given to 4-hour fasted test and standard drug animal groups respectively for 8 days. Urine volume, urinary electrolyte level will be estimated on 24 hrs. collected urine. On 8th day, additionally urinary glucose will be estimated. Result: The Polyherbal formulations produced significant increase in Na+, K+, Cl- excretion, caused alkalinization of urine, showed strong Diuretic index, saluretic index and Natriuretic index. The higher dose of HF produced comparable effect to that of furosemide. Conclusion: As evidenced by the outcome of this study, it is reasonable to infer that the gokhru Kadha possess a significant diuretic activity in mice. Further in-depth studies are required to assess the diuretic activity in combination with the synthetic drugs and to elucidate possible mechanism of action.
Evaluation of invitro antidiabetic, antibacterial and Antioxidant effect of phenolic acid
(AIKTC, 2022-05) Baig, Mirza Anwar; Shaikh, Juned Mohd Jamil (18PH70); Shaikh, Sufreen Banu Abdul Rehman (18PH84); Siddiqui, Murshida Bakar Husain (18PH94); Shaikh Bushra, Firdous Mohammed Asif (19DPH03)
The in-vitro evaluation of antidiabetic, antibacterial, antioxidant activity of caffeic acid was investigated. α amylase inhibition was measured as it is a key enzyme in carbohydrate metabolism. Antioxidant effect was measured by hydroxyl radical scavenging and DPPH method. For antibacterial activity agar well diffusion method was used and staphylococcus aureus was cultured to test it. Caffeic acid significantly inhibited α amylase, DPPH, hydroxy radical scavenging activity. The current study proves that the caffeic acid showed significant antidiabetic, antibacterial and antioxidant effects in vitro studies.
Evaluation of multifacet role of biowaste for pharmaceutical and cosmetic purpose
(AIKTC, 2022-05) Lal, Mariya; Samant, Vedant Bipin (18PH61); Kazi, Nida Imtiyaz (18PH26); Shaikh, Abusaleh Abdulwadood (17PH45); Khan, Ajmat MD. Ali (18PH31); Qureshi, Arbaaz Ilahi (16PH38)
Now a days there are various materials which are obtained which contains chemicals and various inorganic matter which at times causes harm to the people when in use. Hence to overcome this problem we selected a material known as date seed powder which showed number of properties in all aspects. The absorbing properties of the date seed powder made us understand its role as a very powerful adsorbent for various practical aspects. The phytochemical screening which was performed showed us the exact estimation of the pigments that are present in the date seed powder. The stability studies and the coloring properties of the date seed powder helped us to understand the importance and the use of the natural pigments which were present in the biowaste pit. The formulation aspect of the face wash formulation depicted skin soothing effect with less chemicals as compared to tar based charcoal products in market and would cause less irritation to the skin and provide a soothing effect to the skin.
Evaluation of phytoconstituent for anti-parkinson activity using zebrafish as a model organism
(AIKTC, 2020-05) Khan, Firoz; Shaikh, Mohd. Ikram Ikhlaque (16PH52); Ansari, Tamanna Vahajuddin (16PH02); Shaikh, Afzal Sharfuddin (16PH48); Saiwankar, Neeha Nooruddin (16PH40)
Parkinson disease (PD) is the second most common neurodegenerative disorder, after Alzheimer’s disease. The incidence of PD increases after the age of 50 and rapidly increases after the age of 75. PD is characterized by motor and non-motor features. The most common motor symptoms are tremor, rigidity, akinesia (lack of movement), bradykinesia (slow movements), hypokinesia (reduced movement), that occur mainly due to the degeneration of dopaminergic neurons, involved in the movement coordination and located in the substantia nigra pars compacta. However, in later stages of the disease, it affects other brain regions. Since the available medication of the drugs for the treatment of Parkinson’s disease have seen to have many extrapyrimidal side effects and lesser drugs are present of herbal origin. The purpose of this study is to check and evaluate the efficacy of the phytoconstituent (curcumin) in treatment of parkinson’s disease using zebrafish as a model organism . Curcumin, a yellow pigment present in turmeric has been shown to exhibit numerous activities such as antioxidant, anti-inflammatory, antimicrobial, hepatoprotective, anticarcinogenic, thrombosuppressive and cardiovascular as well have potential to show anti Parkinson activity, is extracted from one of the approved methods and characterized using thin layer chromatography technique. Curcumin related to neuroprotection is its anti-oxidant function that can protects substantia nigra neurons, increases striatal dopamine level , which is necessary for the treatment of parkinson’s disease. Keywords: Parkinson’s disease, Zebrafish, Curcumin.
Evaluation of quality control parameters for expired and non-expired chloroquine phosphate tablet (lariago 250mg) ip
(AIKTC, 2022-05) Nikhat, Farhana; Reshma, Y.; Chaudhary, Abdul Wahid (18PH12); Hamdulay, Ilaf Dawood (18PH23); Khan, Mohd Emad (18PH34); Khan, Junaid Emtiyaz (18PH36)
This study aimed to compare the different quality control parameters for expired and non-expired Chloroquine Phosphate tablet formulations. An expiration date, typically labeled by the manufacturer, refers to the time period during which the product is expected to retain its stability, or retain its quality, strength, and purity, when it is stored appropriately according to its labeled storage conditions. In some cases, some study reveals that, if the medicinal products are stored properly it is possible that they can retain stability even beyond their expiration date and are assumed safe to use. While it is important to ensure patient safety, the study is expected to focus on the quality of expired drug and to assess whether the quality of expired medicine deteriorates to what extent. It will also help in understanding potency of the expired formulation after the date of expiry and what are parameters which are affected after expiry date. This work focuses on qualitative evaluation of expired formulation with respect to the non-expired one. The results of this investigation can be utilized to help prepare for public health emergencies (for example, during a terrorist attack, in a war, outbreak of viral-flu, epidemic, pandemic, or earthquake) or drug shortages occurring due to many reasons including manufacturing and quality problems, delays, and discontinuations severe enough to cause local medical supplies to run out.
Extraction of natural colorant from biowaste dates pits (seeds) for pharmaceuticals and cosmetics
(AIKTC, 2020-05) Lal, Maria; Bawani, Al Fahad Firoj (16PH08); Kazi, Afsha Jalaluddin (16PH19); Khan, Saiqa Salamt (16PH26); Khan, Sabir Mohd. Aslam (16PH30)
Extraction of natural starch and preparation of paracetamol tablets
(AIKTC, 2022-05) Rehan, Abdur Rub; Vyawahare, Maithili Pravin (18PH97); Chaudhary, Sahid Abdul Samad (18PH14); Shinde, Snehal Vinod (18PH90); Momin, Md Anas Sabir (16PH31)
Starch has many roles in formation studies blooming in today's time. We can extract starch from various sources and ways accordingly.
Formulation and evaluation of antimicrobial activity of polyherb gel
(AIKTC, 2020-05) Shaikh, Saba; Sarguru, Rimsha Abdul Shakoor (16PH42); Shaikh, Munazza Mohammad Irfan (16PH54); Hawai, Owais (15PH09)
The practice of herbal medicine has existed since prehistoric times as the primary form of medicine. In this space age where the technology has very much advanced, herbal medicines still flourish and are finding exceptional acceptance in both the developing and the developed countries due to their natural origin and lesser side effects. Besides widespread use of botanicals as medicinal products in developing countries, such products are fast becoming a part of the integrative healthcare systems of the industrialized nations, known as complementary and alternative systems of medicine. A number of herbal traditions have come to dominate the practice of alternative medicine. These include the western herbal tradition based on Greek, Roman and medieval sources, the essentially Ayurvedic tradition of India and the Chinese herbal medicine. The traditional Chinese medicine continues as a distinct branch of modern medical practice .The traditional herbal remedies as alternative medicine plays a significant role in South Africa also, where it forms a part of the culture and beliefs of the indigenous population and also features significantly in primary health care. Botanicals or phytomedicines have always been a major component of traditional systems of healing in developing countries, which have also been an integral part of their history and culture. In the ancient Indian system of medicine, Ayurveda and Siddha are such examples [1].
Formulation and evaluation of antiperspirant stick against fungal infection
(AIKTC, 2022-05) Sayed, Ajaz Ahmad; Khan, Tuba Wasi (17PH27); Dalvi, Sahar Ismail (18PH19); Nashra, Shakir Ahmed (18PH54); Shaikh, Iqra Salim (18PH68)
Preparation & Evaluation of Herbal Cosmetic product- Lip Balm Using Sapodilla Fruit Extract.
Formulation and evaluation of in-situ ophthalmic gel
(AIKTC, 2020-05) Baig, Mirza Salman; Patel, Alfiya Ali (16PH07); Patel, Atiya Husain (16PH03); Kazi, Misbah Nasir (16PH22); Chaudhary, Gaurav Shanichara (16PH12)
The delivery of drug to eye suffer major challenges like Jess absorption & bioavailability because of drainage of the drug solution from the ocular tissue etc. In this study in-situ gel was developed to overcome this problem. In-situ gel which is considered to be in the form of a solution at room temperature which then gets transformed into a gel when it is inserted in the eye by the effect of the physiological conditions like ionic strength, pH & the temperature. In present study the gelling property due to body temperature was exploited. Various concentration of poloxamer 188 and poloxamer 407 mixture were prepared and evaluated. Its effect on gelling temperature was studied. Gelling at body temperature was observed for a few formulations. Further, effect of ratio of poloxamer 188 and poloxamer 407 was studied on gelling temperature. Evaluation for the viscosity, pH, and clarity was performed for optimum formulation. In situ gel is promising ophthalmic drug delivery dosage form
Formulation and evaluation of medicated nano soft jelly
(AIKTC, 2020-05) Murugesan, Arulselvan; Sayed, Ayesha Maqbool (16PH04); Bade, Uzma Nazmuddin (16PH05); Sharma, Saransh Umesh (16PH41); Gawde, Soham Dinesh (17DPH61)
Silymarin is the extract of Silybum marianum, or milk thistle, and it is a mixture of flavonolignans (of which silybin is the most prevalent substances) and one flavonoids. It is used in different liver disorders, particularly chronic liver diseases, cirrhosis, because of its antioxidant, anti-inflammatory and anti-fibrotic power. Silymarin also helps with the digestion of fats. Silymarin is associated with poor aqueous solubility and poor bioavailability, which is due to extensive first pass metabolism. The purpose of this study is to develop and characterize medicated Nano jelly of Silymarin for increasing bioavailability and bypass extensive first pass metabolism. The medicated Nano jellies were formulated by heating and congealing method. Batches were prepared using different concentration of gelling agents and almond gum. The prepared batches were evaluated for appearance, viscosity, size less than 240nm, pH (6.54±0.5), drug content (62% to 90%), stability, and syneresis. Analysis was done using UV-Vis Spectrophotometer, FTIR & Zeta sizer. Keywords:- Silymarin, Nanojellies, Gelling Agents, congealing method
Formulation and evaluation of solid dispersion incorporated oro-dispersible tablet
(AIKTC, 2022-05) Baig, Mirza Anwar
Indomethacin is a Non-Steroidal Anti-Inflammatory (NSAID) drug that is used in the treatments of osteoarthritis, bursitis, tendinitis, rheumatoid arthritis, gout, ankylosing spondylitis, and headaches. Indomethacin has a short and unpredictable oral bioavailability due to the drug's poor solubility in the gastrointestinal tract's fluids (GIT) To enhance the aqueous solubility of insoluble drug, polymeric carriers have been used. The investigation of this study was to formulating, evaluating and characterizing solid dispersion of Indomethacin with PEG 6000 and PVP K30 for increasing its dissolution rate and bioavailability. The solid dispersion was formulated by kneading method. The solid dispersion were characterized by Fourier transform infrared spectroscopy. The powder blend were evaluated for pre-compressional studies like bulk density, tapped density, carr’s compressibility index, Hausner ratio and post compressional studies like hardness, friability, wetting time, dissolution test. All the pre and post compressional parameters evaluated were within the pharmacopoeial limits. Indomethacin spectra shows a prominent peak at 320nm which indicates trace amount of methanol did not interfere in absorption. It was concluded that range of absorption lies in ranges of 0.1 to 0.4 and hence it follows beer lambert law. The r² value was found to be 0.9952. From the result it is concluded that Oro-dispersible tablets of poorly soluble drug, Indomethacin showed increased dissolution and thus enhanced bioavailability, improved efficacy and improved patient compliance.
Green synthesis and characterization of bioactive quinazolinone schiff base
(AIKTC, 2020-05) Patil, Jayshree; Shaikh, Heena Babu (16PH49); Satpute, Swati Kulbhushan (16PH43); Bhoir, Rahul Praod (16PH10); Pathan, Shahabaz Abdul Wahab (16PH47)
Schiff bases have gained importance in medicinal and pharmaceutical fields due to a broad spectrum of biological activities and have been utilized as synthons in the preparation of a number of industrial and biologically active compounds. Quinazolines and quinazolinones are medicinally important nitrogen hetero cyclic compounds. The combination of unique structural features, extensive functionalization, and very high biological activity found, both building blocks are tethered together to synthesize new chemical entity (NCE) 3- (benzylideneamino)-2-methyl-quinazolin-4-one, i.e. schiff base using lemon juice as green solvent. Utilization of fruit juices as a natural and biocatalyst permits mild and highly selective transformation and synthesis in a simplistic and environmentally friendly manner. The present synthesis proceeds via synthesis of Methyl-2- acetamidobenzoate from methyl anthranilate followed by cyclization to produce 3-amino-2-methyl quinazolin-4-one which on treament with benzaldehyde produces schiff base.The synthesized product was identified by its physical properties, melting point, TLC, FTIR and characterized by NMR. It is screened for antibacterial and antioxidant properties. Compared with traditional methods, this green method was more convenient and held without generation of pollution in shorter reaction time, safer to analyst, low cost and simple to run. Keywords: Schiff base, Quinazolinone, fruit juice, bio catalyst
Green synthesis of dihydropyrimidinone using solvent free grinding method
(AIKTC, 2022-05) Patil, Jayshree; Sontakke, Anjali (19DPH01); Shaikh, Rushda (19DPH06); Shaikh, Shahbaz (19DPH07); Siddiqui, Kamil (19DPH09); Khan, Tahzeeb (18PH44)
A facile protocol for one pot (Multicomponent) synthesis of Pyrimidinone derivative through Beginelli reaction by completely different inexperienced ways like heating without catalyst, grinding within the presence of catalyst Cerric nitrate (CAN) and ammonium chloride (NH4Cl) has been performed. The reaction has been continuing smoothly below solvent free condition on grinding of mixture of various organic compound i.e Benzaldehyde, ethyl acetoacetate and urea during a mortar. Dihydropyrimidinone area unit the vital bioactive heterocyclic compounds, this has established an attention in revising the new drug entities based mostly upon the dihydropyrimidinone activity. Its intercalary importance in Pharmaceutical and medicative field thanks to its broad biological activities. The analysis is performed and compared for synthesized product exploitation completely different inexperienced ways. It's been additionally screened for antibacterial drug activity. On comparison, it's been found that grinding technique is a smaller amount time intense as compared to heating and was command while not generating any pollution in quicker time interval, safe to analyst and easy to handle. The good thing about this new protocol lies in avoiding the organic solvent, varied substrate, use low-cost or cheap catalyst that all contributes to safer chemistry.

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